Human basic fibroblast growth factor, bFGF
Recombinant human fibroblast growth factor, bFGF - also abbreviated FGF-2 and FGF-ß, is a member of fibroblast growth factor family and can be produced in E. coli as a single, non-glycosylated protein. In humans, different reports shows a predominant localization both in the nucleus and the cytosol, with unknown reason for inconsistency.
In skin, melanocyte and keratinocyte cells form the so-called epidermo-melanic unit. This is partly mediated by cytokines derived from the keratinocytes, which are important for the well-being of melanocytes. One of the cytokines secreted by keratinocytes is bFGF, acting as a mitogen for melanocytes and also promotes melanin synthesis.
 Fibroblast growth factors, 2001
 Expression and purification of a biologically active basic fibroblast growth factor fusion protein, 2003
 Nuclear and Nucleolar Localization of 18-kDa Fibroblast Growth Factor-2 Is Controlled by C-terminal Signals, 2003
 New Insights into the Pathogenesis of Vitiligo: Imbalance of Epidermal Cytokines at Sites of Lesions, 2002
Sequence and Features
- 10COMPATIBLE WITH RFC
- 12COMPATIBLE WITH RFC
- 21Illegal BamHI site found at 403
- 23COMPATIBLE WITH RFC
- 25COMPATIBLE WITH RFC